Article

Dynamic CTCF bridges drive genome organization

2026-05-02

Abstract excerpt

<h4>ABSTRACT</h4> Human CCCTC-binding factor (CTCF) is a crucial factor in genome organization, regulating chromatin looping and gene expression. The loop extrusion model (LEM) designates cohesin as the sole active player and limits CTCF to a passive barrier, though emerging evidence suggests a more dynamic role. Using complementary single-molecule techniques, combining dual- and quad-trap optical tweezers, fluor...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cc8edbf8-9842-5783-a5d9-61c55c63d860
DOI: 10.64898/2026.05.01.721706

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Dynamic CTCF bridges drive genome organizationDOI 10.64898/2026.05.01.721706Read

Nanoscale 3D DNA tracing in single human cells visualizes loop extrusion directly in situSemantic proximity Read

CTCF is a DNA-tension-dependent barrier to cohesin-mediated DNA loop extrusionSemantic proximity Read

Universal dynamics of cohesin-mediated loop extrusionSemantic proximity Read

Chromatin Dynamics are Highly Subdiffusive Across Seven Orders of MagnitudeSemantic proximity Read

Enhancer hubs and loop collisions identified from single-allele topologies.Semantic proximity Read

Cohesin loss eliminates all loop domains, leading to links among superenhancers and downregulation of nearby genesSemantic proximity Read

Loop competition and extrusion model predicts CTCF interaction specificity.Semantic proximity Read

Gene structure heterogeneity drives transcription noise within human chromosomesSemantic proximity Read

Genome-wide absolute quantification of chromatin loopingSemantic proximity Read

Rapid dynamics allow the low-abundance RTEL1 helicase to promote telomere replicationSemantic proximity Read

The Detailed 3D Multi-Loop Aggregate/Rosette Chromatin Architecture and Functional Dynamic Organization of the Human and Mouse GenomesSemantic proximity Read

Extruding transcription elongation loops observed in high-resolution single-cell 3D genomesSemantic proximity Read