Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Binding domain mutations provide insight into CTCF's relationship with chromatin and its contribution to gene regulation.

Cell genomics - 9 Apr 2025

Do Catherine, Jiang Guimei, Cova Giulia, Katsifis Christos C, Narducci Domenic N, Sakellaropoulos Theodore, Vidal Raphael, Lhoumaud Priscillia, Tsirigos Aristotelis, Regis Faye Fara D, Kakabadze Nata, Nora Elphege P, Noyes Marcus, Hansen Anders S, Skok Jane A

Abstract excerpt

Here we used a series of CTCF mutations to explore CTCF's relationship with chromatin and its contribution to gene regulation. CTCF's impact depends on the genomic context of bound sites and the unique binding properties of WT and mutant CTCF proteins. Specifically, CTCF's signal strength is linked to changes in accessibility, and the ability to block cohesin is linked to its binding stability. Multivariate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Binding Sites
Share to CCCTC-Binding Factor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Cycle Proteins

Share to Chromatin

Share to Chromosomal Proteins, Non-Histone

Share to Cohesins

Share to Gene Expression Regulation

Share to Protein Binding

Source

Open in PubMed Open full text

Identifiers

PMID: 40118069
DOI: 10.1016/j.xgen.2025.100813
PMCID: PMC12008812

Genes

CTCF
TF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Binding domain mutations provide insight into CTCF's relationship with chromatin and its contribution to gene regulation.PMID 40118069Read ↗

The coordination between CTCF, cohesin and TFs impacts nucleosome repositioning and chromatin insulation to define state specific 3D chromatin foldingSemantic proximity Read ↗

CTCF haploinsufficiency destabilizes DNA methylation and predisposes to cancer.Semantic proximity Read ↗

Structure-function relationships explain CTCF zinc finger mutation phenotypes in cancer.Semantic proximity Read ↗

CTCF loss mediates unique DNA hypermethylation landscapes in human cancers.Semantic proximity Read ↗

Therapy-associated mutagenesis at CTCF binding sites is shaped by chromatin context and DNA repair capacitySemantic proximity Read ↗

Quantitative genetics of CTCF binding reveal local sequence effects and different modes of X-chromosome association.Semantic proximity Read ↗

DNA sequence quantitatively encodes CTCF-binding affinity at genome scaleSemantic proximity Read ↗

Functional diversity of CTCFs is encoded in their binding motifs.Semantic proximity Read ↗

Somatic mutations in CTCF zinc fingers produce cellular phenotypes explained by structure-function relationshipsSemantic proximity Read ↗

The pathological and genomic impact of CTCF depletion in mammalian model systemsSemantic proximity Read ↗

Machine learning enables pan-cancer identification of mutational hotspots at persistent CTCF binding sites.Semantic proximity Read ↗

Functional Mutations Form at CTCF-Cohesin Binding Sites in Melanoma Due to Uneven Nucleotide Excision Repair across the Motif.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.