Article

CTCF is a DNA-tension-dependent barrier to cohesin-mediated DNA loop extrusion

2022-09-09

Abstract excerpt

In eukaryotes, genomic DNA is extruded into loops by cohesin 1 . By restraining this process, the DNA-binding protein CTCF generates topologically associating domains (TADs) 2-4 that play key roles in gene regulation and recombination during development and disease 1,5-8 . How CTCF establishes TAD boundaries and to what extent these are permeable to cohesin is unknown 9 . To address these questions, we visuali...

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Literature Corpus work: f98e1aef-2507-5320-83f0-9cdf4b2353d0
DOI: 10.1101/2022.09.08.507093

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