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Deep Profiling Identifies Selection of Nonsynonymous Amino Acid Substitutions in HIV-1 Envelope During Early Infection.

AIDS research and human retroviruses - 1 Dec 2020

Ashokkumar Manickam, Pattabiraman Sathyamurthi, Tripathy Srikanth P, Neogi Ujjwal, Hanna Luke Elizabeth

Abstract excerpt

Understanding the evolutionary dynamics of the viruses within an individual at or near the moment of transmission can provide critical inputs for the design of an effective vaccine for HIV infection. In this study, high-throughput sequencing technology was employed to analyze the evolutionary rate in viruses obtained at a single time point from drug-naive recently infected infants and adults in the chronic stage...

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PMID: 32781829
DOI: 10.1089/AID.2020.0143

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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