Article
Using viral diversity to identify HIV-1 variants under HLA-dependent selection in a systematic viral genome-wide screen.
PLoS pathogens - 1 Aug 2024
Neuner-Jehle Nadia, Zeeb Marius, Thorball Christian W, Fellay Jacques, Metzner Karin J, Frischknecht Paul, Neumann Kathrin, Leeman Christine, Rauch Andri, Stöckle Marcel, Huber Michael, Perreau Matthieu, Bernasconi Enos, Notter Julia, Hoffmann Matthias, Leuzinger Karoline, Günthard Huldrych F, Pasin Chloé, Kouyos Roger D
Abstract excerpt
The pathogenesis of HIV-1 infection is governed by a highly dynamic, time-dependent interaction between the host and the viral genome. In this study, we developed a novel systematic approach to assess the host-virus interaction, using average pairwise viral diversity as a proxy for time since infection, and applied this method to nearly whole viral genome sequences (n = 4,464), human leukocyte antigen (HLA)...
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