Article
HIV populations are large and accumulate high genetic diversity in a nonlinear fashion.
Journal of virology - 1 Sept 2013
Maldarelli Frank, Kearney Mary, Palmer Sarah, Stephens Robert, Mican JoAnn, Polis Michael A, Davey Richard T, Kovacs Joseph, Shao Wei, Rock-Kress Diane, Metcalf Julia A, Rehm Catherine, Greer Sarah E, Lucey Daniel L, Danley Kristen, Alter Harvey, Mellors John W, Coffin John M
Abstract excerpt
HIV infection is characterized by rapid and error-prone viral replication resulting in genetically diverse virus populations. The rate of accumulation of diversity and the mechanisms involved are under intense study to provide useful information to understand immune evasion and the development of drug resistance. To characterize the development of viral diversity after infection, we carried out an in-depth...
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