Article
HIV-1 evolution in gag and env is highly correlated but exhibits different relationships with viral load and the immune response.
AIDS (London, England) - 13 Mar 2009
Piantadosi Anne, Chohan Bhavna, Panteleeff Dana, Baeten Jared M, Mandaliya Kishorchandra, Ndinya-Achola Jeckoniah O, Overbaugh Julie
Abstract excerpt
OBJECTIVE: To evaluate relationships between HIV-1 evolution, including immune evasion, and markers of disease progression during chronic infection. DESIGN: HIV-1 evolution and disease progression markers were evaluated over approximately 5 years of infection among 37 Kenyan women from a prospective, seroincident cohort. Evolution was measured in two genes, gag and env, which are primary targets of cellular and...
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