Article
HIV-1 evolution in gag and env is highly correlated but exhibits different relationships with viral load and the immune response.
AIDS (London, England) - 13 Mar 2009
Piantadosi Anne, Chohan Bhavna, Panteleeff Dana, Baeten Jared M, Mandaliya Kishorchandra, Ndinya-Achola Jeckoniah O, Overbaugh Julie
Abstract excerpt
OBJECTIVE: To evaluate relationships between HIV-1 evolution, including immune evasion, and markers of disease progression during chronic infection. DESIGN: HIV-1 evolution and disease progression markers were evaluated over approximately 5 years of infection among 37 Kenyan women from a prospective, seroincident cohort. Evolution was measured in two genes, gag and env, which are primary targets of cellular and...
Topics
- Antibodies, Viral
- CD4 Lymphocyte Count
- Chronic Disease
- Disease Progression
- Epidemiologic Methods
- Epitopes, T-Lymphocyte
- Evolution, Molecular
- Female
- HIV Infections
- HIV-1
- Humans
- Mutation
- T-Lymphocyte Subsets