Article
Transmission of single HIV-1 genomes and dynamics of early immune escape revealed by ultra-deep sequencing.
PloS one - 20 Aug 2010
Fischer Will, Ganusov Vitaly V, Giorgi Elena E, Hraber Peter T, Keele Brandon F, Leitner Thomas, Han Cliff S, Gleasner Cheryl D, Green Lance, Lo Chien-Chi, Nag Ambarish, Wallstrom Timothy C, Wang Shuyi, McMichael Andrew J, Haynes Barton F, Hahn Beatrice H, Perelson Alan S, Borrow Persephone, Shaw George M, Bhattacharya Tanmoy, Korber Bette T
Abstract excerpt
We used ultra-deep sequencing to obtain tens of thousands of HIV-1 sequences from regions targeted by CD8+ T lymphocytes from longitudinal samples from three acutely infected subjects, and modeled viral evolution during the critical first weeks of infection. Previous studies suggested that a single virus established productive infection, but these conclusions were tempered because of limited sampling; now, we...
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