Article
Selective escape from CD8+ T-cell responses represents a major driving force of human immunodeficiency virus type 1 (HIV-1) sequence diversity and reveals constraints on HIV-1 evolution.
Journal of virology - 1 Nov 2005
Allen Todd M, Altfeld Marcus, Geer Shaun C, Kalife Elizabeth T, Moore Corey, O'sullivan Kristin M, Desouza Ivna, Feeney Margaret E, Eldridge Robert L, Maier Erica L, Kaufmann Daniel E, Lahaie Matthew P, Reyor Laura, Tanzi Giancarlo, Johnston Mary N, Brander Christian, Draenert Rika, Rockstroh Jurgen K, Jessen Heiko, Rosenberg Eric S, Mallal Simon A, Walker Bruce D
Abstract excerpt
The sequence diversity of human immunodeficiency virus type 1 (HIV-1) represents a major obstacle to the development of an effective vaccine, yet the forces impacting the evolution of this pathogen remain unclear. To address this issue we assessed the relationship between genome-wide viral evolution and adaptive CD8+ T-cell responses in four clade B virus-infected patients studied longitudinally for as long as 5...
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