Article
Short communication: HIV-1 gag genetic variation in a single acutely infected participant defined by high-resolution deep sequencing.
AIDS research and human retroviruses - 1 Aug 2014
Al-Mawsawi Laith Q, Wu Nicholas C, De La Cruz Justin, Shi Vivian Cai, Wu Ting-Ting, Daar Eric S, Lewis Martha J, Yang Otto O, Sun Ren
Abstract excerpt
Acute HIV-1 infection is characterized by the rapid generation of highly diverse genetic variants to adapt to the new host environment. Understanding the dynamics of viral genetic variation at this stage of infection is critical for vaccine design efforts and early drug treatment. Here, using a high-resolution deep sequencing approach targeting the HIV-1 gag region, we reveal very early immune pressure with...
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