A Trio of Active Zone Proteins Comprised of RIM-BPs, RIMs, and Munc13s Governs Neurotransmitter Release.

doi:10.1016/j.celrep.2020.107960

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Article

A Trio of Active Zone Proteins Comprised of RIM-BPs, RIMs, and Munc13s Governs Neurotransmitter Release.

Cell reports - 4 Aug 2020

Brockmann Marisa M, Zarebidaki Fereshteh, Camacho Marcial, Grauel M Katharina, Trimbuch Thorsten, Südhof Thomas C, Rosenmund Christian

Abstract excerpt

At the presynaptic active zone, action-potential-triggered neurotransmitter release requires that fusion-competent synaptic vesicles are placed next to Ca2+ channels. The active zone resident proteins RIM, RBP, and Munc13 are essential contributors for vesicle priming and Ca2+-channel recruitment. Although the individual contributions of these scaffolds have been extensively studied, their respective functions in...

Topics

Animals
Calcium
Cytoskeletal Proteins
Gene Deletion
HEK293 Cells
Hippocampus
Humans
Mice, Inbred C57BL
Mice, Knockout
Nerve Tissue Proteins
Neurons

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neurotransmitter Agents

Phenotype

Presynaptic Terminals

Protein Binding

Synaptic Transmission

Synaptic Vesicles

rab3 GTP-Binding Proteins

Source

Open in PubMed

Identifiers

PMID: 32755572
DOI: 10.1016/j.celrep.2020.107960

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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A Trio of Active Zone Proteins Comprised of RIM-BPs, RIMs, and Munc13s Governs Neurotransmitter Release.PMID 32755572Read ↗

RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zone.Semantic proximity Read ↗

RIM-binding protein, a central part of the active zone, is essential for neurotransmitter release.Semantic proximity Read ↗

Liprin-α/RIM complex regulates the dynamic assembly of presynaptic active zones via liquid-liquid phase separationSemantic proximity Read ↗

Control of neurotransmitter release by two distinct membrane-binding faces of the Munc13-1 C1C2B region.Semantic proximity Read ↗

RIM1α SUMOylation is required for fast synaptic vesicle exocytosis.Semantic proximity Read ↗

Rim, a component of the presynaptic active zone and modulator of exocytosis, binds 14-3-3 through its N terminus.Semantic proximity Read ↗

Liprin-α2 promotes the presynaptic recruitment and turnover of RIM1/CASK to facilitate synaptic transmission.Semantic proximity Read ↗

Oligomerized liprin-α promotes phase separation of ELKS for compartmentalization of presynaptic active zone proteins.Semantic proximity Read ↗

RIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses.Semantic proximity Read ↗

Rim is a putative Rab3 effector in regulating synaptic-vesicle fusion.Semantic proximity Read ↗

A post-docking role for active zone protein Rim.Semantic proximity Read ↗

Nonconserved Ca(2+)/calmodulin binding sites in Munc13s differentially control synaptic short-term plasticity.Semantic proximity Read ↗

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