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Article

A Trio of Active Zone Proteins Comprised of RIM-BPs, RIMs, and Munc13s Governs Neurotransmitter Release.

Cell reports - 4 Aug 2020

Brockmann Marisa M, Zarebidaki Fereshteh, Camacho Marcial, Grauel M Katharina, Trimbuch Thorsten, Südhof Thomas C, Rosenmund Christian

Abstract excerpt

At the presynaptic active zone, action-potential-triggered neurotransmitter release requires that fusion-competent synaptic vesicles are placed next to Ca2+ channels. The active zone resident proteins RIM, RBP, and Munc13 are essential contributors for vesicle priming and Ca2+-channel recruitment. Although the individual contributions of these scaffolds have been extensively studied, their respective functions in...

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Source

Identifiers

PMID: 32755572
DOI: 10.1016/j.celrep.2020.107960

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Trio of Active Zone Proteins Comprised of RIM-BPs, RIMs, and Munc13s Governs Neurotransmitter Release.PMID 32755572Read ↗

RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zone.Semantic proximity Read ↗

RIM-binding protein, a central part of the active zone, is essential for neurotransmitter release.Semantic proximity Read ↗

Liprin-α/RIM complex regulates the dynamic assembly of presynaptic active zones via liquid-liquid phase separationSemantic proximity Read ↗

The liprin-α/RIM complex regulates the dynamic assembly of presynaptic active zones via liquid-liquid phase separation.Semantic proximity Read ↗

Control of neurotransmitter release by two distinct membrane-binding faces of the Munc13-1 C1C2B region.Semantic proximity Read ↗

RIM1α SUMOylation is required for fast synaptic vesicle exocytosis.Semantic proximity Read ↗

Rim, a component of the presynaptic active zone and modulator of exocytosis, binds 14-3-3 through its N terminus.Semantic proximity Read ↗

Liprin-α2 promotes the presynaptic recruitment and turnover of RIM1/CASK to facilitate synaptic transmission.Semantic proximity Read ↗

Oligomerized liprin-α promotes phase separation of ELKS for compartmentalization of presynaptic active zone proteins.Semantic proximity Read ↗

RIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses.Semantic proximity Read ↗

Rim is a putative Rab3 effector in regulating synaptic-vesicle fusion.Semantic proximity Read ↗

A post-docking role for active zone protein Rim.Semantic proximity Read ↗

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