Article
The liprin-α/RIM complex regulates the dynamic assembly of presynaptic active zones via liquid-liquid phase separation.
PLoS biology - 1 Jun 2025
Jin Gaowei, Campos Joaquín, Liu Yang, de la Cruz Berta Marcó, Zhang Shujing, Liang Mingfu, Li Kaiyue, Xie Xingqiao, Sterky Fredrik H, Acuna Claudio, Wei Zhiyi
Abstract excerpt
Presynaptic scaffold proteins, including liprin-α, RIM, and ELKS, are pivotal to the assembly of the active zone and regulating the coupling of calcium signals and neurotransmitter release, yet the underlying mechanism remains poorly understood. Here, we determined the crystal structure of the liprin-α2/RIM1 complex, revealing a multifaceted intermolecular interaction that drives the liprin-α/RIM assembly....
Read the complete abstract on PubMedTopics
- Humans
- Synaptic Vesicles
- Synaptic Transmission
- Presynaptic Terminals
- Neurons
- Adaptor Proteins, Signal Transducing