Article
RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zone.
Nature - 17 Jan 2002
Schoch Susanne, Castillo Pablo E, Jo Tobias, Mukherjee Konark, Geppert Martin, Wang Yun, Schmitz Frank, Malenka Robert C, Südhof Thomas C
Abstract excerpt
Neurotransmitters are released by synaptic vesicle fusion at the active zone. The active zone of a synapse mediates Ca2+-triggered neurotransmitter release, and integrates presynaptic signals in regulating this release. Much is known about the structure of active zones and synaptic vesicles, but the functional relation between their components is poorly understood. Here we show that RIM1alpha, an active zone...
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