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Article

A post-docking role for active zone protein Rim.

Nature neuroscience - 1 Oct 2001

Koushika S P, Richmond J E, Hadwiger G, Weimer R M, Jorgensen E M, Nonet M L

Abstract excerpt

Rim1 was previously identified as a Rab3 effector localized to the presynaptic active zone in vertebrates. Here we demonstrate that C. elegans unc-10 mutants lacking Rim are viable, but exhibit behavioral and physiological defects that are more severe than those of Rab3 mutants. Rim is localized to synaptic sites in C. elegans, but the ultrastructure of the presynaptic densities is normal in Rim mutants....

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Identifiers

PMID: 11559854
DOI: 10.1038/nn732
PMCID: PMC2585766

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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A post-docking role for active zone protein Rim.PMID 11559854Read ↗

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RIM-binding protein, a central part of the active zone, is essential for neurotransmitter release.Semantic proximity Read ↗

A Trio of Active Zone Proteins Comprised of RIM-BPs, RIMs, and Munc13s Governs Neurotransmitter Release.Semantic proximity Read ↗

The presynaptic dense projection of the Caenorhabditis elegans cholinergic neuromuscular junction localizes synaptic vesicles at the active zone through SYD-2/liprin and UNC-10/RIM-dependent interactions.Semantic proximity Read ↗

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