Article
Liprin-α2 promotes the presynaptic recruitment and turnover of RIM1/CASK to facilitate synaptic transmission.
The Journal of cell biology - 10 Jun 2013
Spangler Samantha A, Schmitz Sabine K, Kevenaar Josta T, de Graaff Esther, de Wit Heidi, Demmers Jeroen, Toonen Ruud F, Hoogenraad Casper C
Abstract excerpt
The presynaptic active zone mediates synaptic vesicle exocytosis, and modulation of its molecular composition is important for many types of synaptic plasticity. Here, we identify synaptic scaffold protein liprin-α2 as a key organizer in this process. We show that liprin-α2 levels were regulated by synaptic activity and the ubiquitin-proteasome system. Furthermore, liprin-α2 organized presynaptic ultrastructure...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.