Article

Liprin-α/RIM complex regulates the dynamic assembly of presynaptic active zones via liquid-liquid phase separation

2024-08-30

Abstract excerpt

Presynaptic scaffold proteins, including liprin-α, RIM, and ELKS, are pivotal to the assembly of the active zone and regulating the coupling of calcium signals and neurotransmitter release, yet the underlying mechanism remains poorly understood. Here, we determined the crystal structure of the liprin-α2/RIM1 complex, revealing a multifaceted intermolecular interaction that drives the liprin-α/RIM assembly. Neurode...

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Literature Corpus work: 50fd2e34-9b9b-5ef0-abc1-7f23cbaf9e3f
DOI: 10.1101/2024.08.29.610253

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