RIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses.

doi:10.1073/pnas.1605256113

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Article

RIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses.

Proceedings of the National Academy of Sciences of the United States of America - 11 Oct 2016

Grauel M Katharina, Maglione Marta, Reddy-Alla Suneel, Willmes Claudia G, Brockmann Marisa M, Trimbuch Thorsten, Rosenmund Tanja, Pangalos Maria, Vardar Gülçin, Stumpf Alexander, Walter Alexander M, Rost Benjamin R, Eickholt Britta J, Haucke Volker, Schmitz Dietmar, Sigrist Stephan J, Rosenmund Christian

Abstract excerpt

The tight spatial coupling of synaptic vesicles and voltage-gated Ca2+ channels (CaVs) ensures efficient action potential-triggered neurotransmitter release from presynaptic active zones (AZs). Rab-interacting molecule-binding proteins (RIM-BPs) interact with Ca2+ channels and via RIM with other components of the release machinery. Although human RIM-BPs have been implicated in autism spectrum disorders, little...

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PMID: 27671655
DOI: 10.1073/pnas.1605256113
PMCID: PMC5068320

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