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Article

Control of neurotransmitter release by two distinct membrane-binding faces of the Munc13-1 C1C2B region.

eLife - 15 Nov 2021

Camacho Marcial, Quade Bradley, Trimbuch Thorsten, Xu Junjie, Sari Levent, Rizo Josep, Rosenmund Christian

Abstract excerpt

Munc13-1 plays a central role in neurotransmitter release through its conserved C-terminal region, which includes a diacyglycerol (DAG)-binding C1 domain, a Ca2+/PIP2-binding C2B domain, a MUN domain and a C2C domain. Munc13-1 was proposed to bridge synaptic vesicles to the plasma membrane through distinct interactions of the C1C2B region with the plasma membrane: (i) one involving a polybasic face that is...

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Identifiers

PMID: 34779770
DOI: 10.7554/eLife.72030
PMCID: PMC8648301

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