Article
RIM1α SUMOylation is required for fast synaptic vesicle exocytosis.
Cell reports - 12 Dec 2013
Girach Fatima, Craig Tim J, Rocca Daniel L, Henley Jeremy M
Abstract excerpt
The rapid, activity-dependent quantal presynaptic release of neurotransmitter is vital for brain function. The complex process of vesicle priming, fusion, and retrieval is very precisely controlled and requires the spatiotemporal coordination of multiple protein-protein interactions. Here, we show that posttranslational modification of the active zone protein Rab3-interacting molecule 1α (RIM1α) by the small...
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