Article
Oligomerized liprin-α promotes phase separation of ELKS for compartmentalization of presynaptic active zone proteins.
Cell reports - 23 Mar 2021
Liang Mingfu, Jin Gaowei, Xie Xingqiao, Zhang Wenchao, Li Kaiyue, Niu Fengfeng, Yu Cong, Wei Zhiyi
Abstract excerpt
Synaptic scaffold proteins (e.g., liprin-α, ELKS, RIM, and RIM-BP) orchestrate ion channels, receptors, and enzymes at presynaptic terminals to form active zones for neurotransmitter release. The underlying mechanism of the active zone assembly remains elusive. Here, we report that liprin-α proteins have the potential to oligomerize through the N-terminal coiled-coil region. Our structural and biochemical...
Topics
- Adaptor Proteins, Signal Transducing
- GTP-Binding Proteins
- HEK293 Cells
- Humans
- Membrane Proteins
- Mutation
- Nerve Tissue Proteins
- Protein Multimerization
- Protein Structure, Secondary
- Synapses