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Article

Rim, a component of the presynaptic active zone and modulator of exocytosis, binds 14-3-3 through its N terminus.

The Journal of biological chemistry - 3 Oct 2003

Sun Lei, Bittner Mary A, Holz Ronald W

Abstract excerpt

Rim1, a brain-specific Rab3a-binding protein, localizes to the presynaptic cytomatrix and plays an important role in synaptic transmission and synaptic plasticity. Rim2, a homologous protein, is more ubiquitously expressed and is found in neuroendocrine cells as well as in brain. Both Rim1 and Rim2 contain multiple domains, including an N-terminal zinc finger, which in Rim1 strongly enhances secretion in...

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Source

Identifiers

PMID: 12871946
DOI: 10.1074/jbc.M212801200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Rim, a component of the presynaptic active zone and modulator of exocytosis, binds 14-3-3 through its N terminus.PMID 12871946Read ↗

Rim is a putative Rab3 effector in regulating synaptic-vesicle fusion.Semantic proximity Read ↗

A Trio of Active Zone Proteins Comprised of RIM-BPs, RIMs, and Munc13s Governs Neurotransmitter Release.Semantic proximity Read ↗

RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zone.Semantic proximity Read ↗

RIM-binding protein, a central part of the active zone, is essential for neurotransmitter release.Semantic proximity Read ↗

Disruption of Rab3-calmodulin interaction, but not other effector interactions, prevents Rab3 inhibition of exocytosis.Semantic proximity Read ↗

A direct inhibitory role for the Rab3-specific effector, Noc2, in Ca2+-regulated exocytosis in neuroendocrine cells.Semantic proximity Read ↗

RIM1α SUMOylation is required for fast synaptic vesicle exocytosis.Semantic proximity Read ↗

A post-docking role for active zone protein Rim.Semantic proximity Read ↗

RIM controls homeostatic plasticity through modulation of the readily-releasable vesicle pool.Semantic proximity Read ↗

Liprin-α/RIM complex regulates the dynamic assembly of presynaptic active zones via liquid-liquid phase separationSemantic proximity Read ↗

Liprin-α2 promotes the presynaptic recruitment and turnover of RIM1/CASK to facilitate synaptic transmission.Semantic proximity Read ↗

Direct interactions between C. elegans RAB-3 and Rim provide a mechanism to target vesicles to the presynaptic density.Semantic proximity Read ↗

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