Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rim is a putative Rab3 effector in regulating synaptic-vesicle fusion.

Nature - 7 Aug 1997

Wang Y, Okamoto M, Schmitz F, Hofmann K, Südhof T C

Abstract excerpt

Rab3 is a neuronal GTP-binding protein that regulates fusion of synaptic vesicles and is essential for long-term potentiation of hippocampal mossy fibre synapses. More than thirty Rab GTP-binding proteins are known to function in diverse membrane transport pathways, although their mechanisms of action are unclear. We have now identified a putative Rab3-effector protein called Rim. Rim is composed of an...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Brain
Share to Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Molecular Sequence Data

Share to Mutation

Share to Nerve Tissue Proteins

Share to Recombinant Fusion Proteins

Source

Identifiers

PMID: 9252191
DOI: 10.1038/41580

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rim is a putative Rab3 effector in regulating synaptic-vesicle fusion.PMID 9252191Read ↗

Rim, a component of the presynaptic active zone and modulator of exocytosis, binds 14-3-3 through its N terminus.Semantic proximity Read ↗

RIM-binding protein, a central part of the active zone, is essential for neurotransmitter release.Semantic proximity Read ↗

A Trio of Active Zone Proteins Comprised of RIM-BPs, RIMs, and Munc13s Governs Neurotransmitter Release.Semantic proximity Read ↗

RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zone.Semantic proximity Read ↗

RIM controls homeostatic plasticity through modulation of the readily-releasable vesicle pool.Semantic proximity Read ↗

A direct inhibitory role for the Rab3-specific effector, Noc2, in Ca2+-regulated exocytosis in neuroendocrine cells.Semantic proximity Read ↗

Direct interactions between C. elegans RAB-3 and Rim provide a mechanism to target vesicles to the presynaptic density.Semantic proximity Read ↗

RIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses.Semantic proximity Read ↗

RIM1α SUMOylation is required for fast synaptic vesicle exocytosis.Semantic proximity Read ↗

A post-docking role for active zone protein Rim.Semantic proximity Read ↗

Disruption of Rab3-calmodulin interaction, but not other effector interactions, prevents Rab3 inhibition of exocytosis.Semantic proximity Read ↗

Upregulation of RIN3 induces endosomal dysfunction in Alzheimer’s diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.