Article
RIM-binding protein, a central part of the active zone, is essential for neurotransmitter release.
Science (New York, N.Y.) - 16 Dec 2011
Liu Karen S Y, Siebert Matthias, Mertel Sara, Knoche Elena, Wegener Stephanie, Wichmann Carolin, Matkovic Tanja, Muhammad Karzan, Depner Harald, Mettke Christoph, Bückers Johanna, Hell Stefan W, Müller Martin, Davis Graeme W, Schmitz Dietmar, Sigrist Stephan J
Abstract excerpt
The molecular machinery mediating the fusion of synaptic vesicles (SVs) at presynaptic active zone (AZ) membranes has been studied in detail, and several essential components have been identified. AZ-associated protein scaffolds are viewed as only modulatory for transmission. We discovered that Drosophila Rab3-interacting molecule (RIM)-binding protein (DRBP) is essential not only for the integrity of the AZ...
Topics
- Animals
- Calcium Channels
- Carrier Proteins
- Drosophila
- Drosophila Proteins
- Male
- Mutation
- Neurotransmitter Agents
- Presynaptic Terminals
- Synapses