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Article

Nucleoid remodeling during environmental adaptation is regulated by HU-dependent DNA bundling.

Nature communications - 9 Jun 2020

Remesh Soumya G, Verma Subhash C, Chen Jian-Hua, Ekman Axel A, Larabell Carolyn A, Adhya Sankar, Hammel Michal

Abstract excerpt

Bacterial nucleoid remodeling dependent on conserved histone-like protein, HU is one of the determining factors in global gene regulation. By imaging of near-native, unlabeled E. coli cells by soft X-ray tomography, we show that HU remodels nucleoids by promoting the formation of a dense condensed core surrounded by less condensed isolated domains. Nucleoid remodeling during cell growth and environmental...

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Identifiers

PMID: 32518228
DOI: 10.1038/s41467-020-16724-5
PMCID: PMC7283360

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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