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Article

Homeostatic regulation of supercoiling sensitivity coordinates transcription of the bacterial genome.

EMBO reports - 1 Jul 2006

Blot Nicolas, Mavathur Ramesh, Geertz Marcel, Travers Andrew, Muskhelishvili Georgi

Abstract excerpt

Regulation of cellular growth implies spatiotemporally coordinated programmes of gene transcription. A central question, therefore, is how global transcription is coordinated in the genome. The growth of the unicellular organism Escherichia coli is associated with changes in both the global superhelicity modulated by cellular topoisomerase activity and the relative proportions of the abundant DNA-architectural...

Topics

Bacterial Proteins
Chromatin
DNA, Bacterial
DNA, Superhelical
DNA-Binding Proteins
Escherichia coli
Escherichia coli Proteins
Factor For Inversion Stimulation Protein
Genome, Bacterial
Homeostasis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Models, Biological

Mutation

Oligonucleotide Array Sequence Analysis

Transcription Factors

Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 16799466
DOI: 10.1038/sj.embor.7400729
PMCID: PMC1500834

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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