Article

Distinct principles of genome compartmentalization in <i>Drosophila</i> and humans revealed by osmotic stress

2026-04-06

Abstract excerpt

The three-dimensional organization of eukaryotic genomes into compartments, topologically associating domains, and loops is mediated by architectural proteins whose organizational principles vary across species. In Drosophila , insulator proteins including Su(Hw) and the histone variant γH2Av form liquid-liquid phase separation (LLPS) condensates, yet how this phase separation capacity relates to genome compartme...

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Literature Corpus work: 3425deaa-c92b-5da9-b643-d4e581cd7e89
DOI: 10.64898/2026.04.02.716189

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