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Article

Right-handed DNA supercoiling by an octameric form of histone-like protein HU: modulation of cellular transcription.

The Journal of biological chemistry - 29 Dec 2006

Kar Sudeshna, Choi Eugene J, Guo Fusheng, Dimitriadis Emilios K, Kotova Svetlana L, Adhya Sankar

Abstract excerpt

In bacteria, the contribution of global nucleoid organization in determining cellular transcription programs is unclear. Using a mutant form of the most abundant nucleoid-associated protein HU, HUalpha(E38K,V42L), we previously showed that nucleoid remodeling by the mutant protein re-organizes the global transcription pattern. Here, we demonstrate that, unlike the dimeric wild-type HU, HUalpha(E38K,V42L) is an...

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PMID: 17062578
DOI: 10.1074/jbc.M605576200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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