Article

OptiFoot: a method for recording protein footprints on DNA for microscopy and sequence analysis

2026-05-14

Abstract excerpt

A comprehensive understanding of protein–nucleic acid interactions in the crowded nuclear milieu is essential for elucidating genome function. State-of-the art methods provide the finest details of genome organization, but lack integration of imaging and sequencing modalities. We introduce OptiFoot, a fluorescence-based platform for recording protein–nucleic acid interactions in cells. OptiFoot employs an engineer...

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Literature Corpus work: fb01f302-f875-5c61-8e87-a82975615c00
DOI: 10.64898/2026.05.12.724470

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