Article
Coordination of genomic structure and transcription by the main bacterial nucleoid-associated protein HU.
EMBO reports - 1 Jan 2010
Berger Michael, Farcas Anca, Geertz Marcel, Zhelyazkova Petya, Brix Klaudia, Travers Andrew, Muskhelishvili Georgi
Abstract excerpt
The histone-like protein HU is a highly abundant DNA architectural protein that is involved in compacting the DNA of the bacterial nucleoid and in regulating the main DNA transactions, including gene transcription. However, the coordination of the genomic structure and function by HU is poorly understood. Here, we address this question by comparing transcript patterns and spatial distributions of RNA polymerase...
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