Article
Nucleoid-associated proteins affect mutation dynamics in E. coli in a growth phase-specific manner.
PLoS computational biology - 1 Jan 2012
Warnecke Tobias, Supek Fran, Lehner Ben
Abstract excerpt
The binding of proteins can shield DNA from mutagenic processes but also interfere with efficient repair. How the presence of DNA-binding proteins shapes intra-genomic differences in mutability and, ultimately, sequence variation in natural populations, however, remains poorly understood. In this study, we examine sequence evolution in Escherichia coli in relation to the binding of four abundant...
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