Article

Discovering the drivers of clonal hematopoiesis

2020-10-23

Abstract excerpt

Mutations in genes that confer a selective advantage to hematopoietic stem cells (HSCs) in certain conditions drive clonal hematopoiesis (CH). While some CH drivers have been identified experimentally or through epidemiological studies, the compendium of all genes able to drive CH upon mutations in HSCs is far from complete. We propose that identifying signals of positive selection in blood somatic mutations may b...

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Literature Corpus work: 0d14a16c-b5f3-59ae-8c4a-971df384f77f
DOI: 10.1101/2020.10.22.350140

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