Article
Population dynamics of normal human blood inferred from somatic mutations.
Nature - 1 Sept 2018
Lee-Six Henry, Øbro Nina Friesgaard, Shepherd Mairi S, Grossmann Sebastian, Dawson Kevin, Belmonte Miriam, Osborne Robert J, Huntly Brian J P, Martincorena Inigo, Anderson Elizabeth, O'Neill Laura, Stratton Michael R, Laurenti Elisa, Green Anthony R, Kent David G, Campbell Peter J
Abstract excerpt
Haematopoietic stem cells drive blood production, but their population size and lifetime dynamics have not been quantified directly in humans. Here we identified 129,582 spontaneous, genome-wide somatic mutations in 140 single-cell-derived haematopoietic stem and progenitor colonies from a healthy 59-year-old man and applied population-genetics approaches to reconstruct clonal dynamics. Cell divisions from early...
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