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Article

Consequences of HLA-associated mutations in HIV-1 subtype C Nef on HLA-I downregulation ability.

Journal of medical virology - 1 Aug 2020

Mann Jaclyn K, Rajkoomar Erasha, Jin Steven W, Mkhize Qiniso, Baiyegunhi Omolara, Mbona Pholisiwe, Brockman Mark A, Ndung'u Thumbi

Abstract excerpt

Identification of CD8+ T lymphocyte (CTL) escape mutations that compromise the pathogenic functions of the Nef protein may be relevant for an HIV-1 attenuation-based vaccine. Previously, HLA-associated mutations 102H, 105R, 108D, and 199Y were individually statistically associated with decreased Nef-mediated HLA-I downregulation ability in a cohort of 298 HIV-1 subtype C infected individuals. In the present...

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Share to HIV-1
Share to CD8-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Line

Share to Down-Regulation

Share to Genes, MHC Class I

Share to HIV Infections

Share to Mutagenesis, Site-Directed

Share to nef Gene Products, Human Immunodeficiency Virus

Source

Identifiers

PMID: 31944317
DOI: 10.1002/jmv.25676

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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