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Article

Dynamic Evolution of the Human Immunodeficiency Virus Type 1 Pathogenic Factor, Nef

13 Jan 2006

Abstract excerpt

The human immunodeficiency virus type 1 (HIV-1) early gene product Nef is a multifunctional protein that alters numerous pathways of T-cell function, including endocytosis, signal transduction, vesicular trafficking, and immune modulation, and is a major determinant of pathogenesis. Individual Nef functions include PAK-2 activation, CD4 downregulation, major histocompatibility complex (MHC) class I...

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Identifiers

PMID: 16415008
DOI: 10.1128/jvi.80.3.1311-1320.2006

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