Article
Ability of HIV-1 Nef to downregulate CD4 and HLA class I differs among viral subtypes.
Retrovirology - 16 Sept 2013
Mann Jaclyn K, Byakwaga Helen, Kuang Xiaomei T, Le Anh Q, Brumme Chanson J, Mwimanzi Philip, Omarjee Saleha, Martin Eric, Lee Guinevere Q, Baraki Bemuluyigza, Danroth Ryan, McCloskey Rosemary, Muzoora Conrad, Bangsberg David R, Hunt Peter W, Goulder Philip J R, Walker Bruce D, Harrigan P Richard, Martin Jeff N, Ndung'u Thumbi, Brockman Mark A, Brumme Zabrina L
Abstract excerpt
BACKGROUND: The highly genetically diverse HIV-1 group M subtypes may differ in their biological properties. Nef is an important mediator of viral pathogenicity; however, to date, a comprehensive inter-subtype comparison of Nef in vitro function has not been undertaken. Here, we investigate two of Nef's most well-characterized activities, CD4 and HLA class I downregulation, for clones obtained from 360 chronic...
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