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Article

Relative Resistance of HLA-B to Downregulation by Naturally Occurring HIV-1 Nef Sequences.

mBio - 19 Jan 2016

Mahiti Macdonald, Toyoda Mako, Jia Xiaofei, Kuang Xiaomei T, Mwimanzi Francis, Mwimanzi Philip, Walker Bruce D, Xiong Yong, Brumme Zabrina L, Brockman Mark A, Ueno Takamasa

Abstract excerpt

UNLABELLED: HIV-1 Nef binds to the cytoplasmic region of HLA-A and HLA-B and downregulates these molecules from the surface of virus-infected cells, thus evading immune detection by CD8(+) T cells. Polymorphic residues within the HLA cytoplasmic region may affect Nef's downregulation activity. However, the effects of HLA polymorphisms on recognition by primary Nef isolates remain elusive, as do the specific Nef...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26787826
DOI: 10.1128/mBio.01516-15
PMCID: PMC4724998

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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