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Article

Genetic determinants of Nef-mediated CD4 and HLA class I down-regulation differences between HIV-1 subtypes B and C.

Virology journal - 25 Nov 2015

Mann Jaclyn K, Omarjee Saleha, Khumalo Phumzile, Ndung'u Thumbi

Abstract excerpt

BACKGROUND: HIV-1 subtype C Nef sequences have a significantly lower ability overall to down-regulate CD4 and HLA-I than subtype B Nef sequences. Here we investigated whether Nef amino acids differing in frequency between HIV-1 subtypes B and C explain lower CD4 and HLA-I down-regulation ability of subtype C. FINDINGS: Subtype-specific mutations were introduced into representative subtype B and C Nef sequences...

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Topics

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Share to CD4 Antigens
Share to CD4-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Down-Regulation

Share to Flow Cytometry

Share to Histocompatibility Antigens Class I

Share to Host-Pathogen Interactions

Share to Mutagenesis, Site-Directed

Share to nef Gene Products, Human Immunodeficiency Virus

Source

Open in PubMed Open full text

Identifiers

PMID: 26607225
DOI: 10.1186/s12985-015-0429-7
PMCID: PMC4660847

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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