Article
Resistance of Major Histocompatibility Complex Class B (MHC-B) to Nef-Mediated Downregulation Relative to that of MHC-A Is Conserved among Primate Lentiviruses and Influences Antiviral T Cell Responses in HIV-1-Infected Individuals.
Journal of virology - 1 Jan 2018
Mwimanzi Francis, Toyoda Mako, Mahiti Macdonald, Mann Jaclyn K, Martin Jeffrey N, Bangsberg David, Brockman Mark A, Goulder Philip, Kirchhoff Frank, Brumme Zabrina L, Ndung'u Thumbi, Ueno Takamasa
Abstract excerpt
Patient-derived HIV-1 subtype B Nef clones downregulate HLA-A more efficiently than HLA-B. However, it remains unknown whether this property is common to Nef proteins across primate lentiviruses and how antiviral immune responses may be affected. We examined 263 Nef clones from diverse primate lentiviruses including different pandemic HIV-1 group M subtypes for their ability to downregulate major...
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