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Article

Nef-specific CD8+ T cell responses contribute to HIV-1 immune control.

PloS one - 1 Jan 2013

Adland Emily, Carlson Jonathan M, Paioni Paolo, Kløverpris Henrik, Shapiro Roger, Ogwu Anthony, Riddell Lynn, Luzzi Graz, Chen Fabian, Balachandran Thambiah, Heckerman David, Stryhn Anette, Edwards Anne, Ndung'u Thumbi, Walker Bruce D, Buus Søren, Goulder Philip, Matthews Philippa C

Abstract excerpt

Recent studies in the SIV-macaque model of HIV infection suggest that Nef-specific CD8+ T-cell responses may mediate highly effective immune control of viraemia. In HIV infection Nef recognition dominates in acute infection, but in large cohort studies of chronically infected subjects, breadth of T cell responses to Nef has not been correlated with significant viraemic control. Improved disease outcomes have...

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Share to CD8-Positive T-Lymphocytes
Share to Conserved Sequence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HLA-B Antigens

Share to Immunization

Share to nef Gene Products, Human Immunodeficiency Virus

Share to Selection, Genetic

Share to Viral Load

Source

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Identifiers

PMID: 24023819
DOI: 10.1371/journal.pone.0073117
PMCID: PMC3759414

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Nef-specific CD8+ T cell responses contribute to HIV-1 immune control.PMID 24023819Read ↗

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