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Consequences of HLA-B*13-Associated Escape Mutations on HIV-1 Replication and Nef Function

10 Sept 2015

Abstract excerpt

UNLABELLED: HLA-B*13 is associated with superior in vivo HIV-1 viremia control. Protection is thought to be mediated by sustained targeting of key cytotoxic T lymphocyte (CTL) epitopes and viral fitness costs of CTL escape in Gag although additional factors may contribute. We assessed the impact of 10 published B*13-associated polymorphisms in Gag, Pol, and Nef, in 23 biologically relevant combinations, on HIV-1...

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PMID: 26355081
DOI: 10.1128/jvi.01955-15

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