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Article

An HIV-1 Nef genotype that diminishes immune control mediated by protective human leucocyte antigen alleles.

AIDS (London, England) - 15 Jul 2020

Mwimanzi Francis, Ngare Isaac, Toyoda Mako, Mori Masahiko, Mann Jaclyn, Ndung'u Thumbi, Goulder Phillip, Ueno Takamasa

Abstract excerpt

OBJECTIVES: Certain human leucocyte antigen (HLA)-B alleles (protective alleles) associate with durable immune control of HIV-1, but with substantial heterogeneity in the level of control. It remains elusive whether viral factors including Nef-mediated immune evasion function diminish protective allele effect on viral control. DESIGN: The naturally occurring non-Ser variant at position 9 of HIV-1 subtype C Nef...

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PMID: 32590431
DOI: 10.1097/QAD.0000000000002559

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