Article
Human leukocyte antigen (HLA) class I down-regulation by human immunodeficiency virus type 1 negative factor (HIV-1 Nef): what might we learn from natural sequence variants?
Viruses - 1 Sept 2012
Mwimanzi Philip, Markle Tristan J, Ueno Takamasa, Brockman Mark A
Abstract excerpt
HIV-1 causes a chronic infection in humans that is characterized by high plasma viremia, progressive loss of CD4+ T lymphocytes, and severe immunodeficiency resulting in opportunistic disease and AIDS. Viral persistence is mediated in part by the ability of the Nef protein to down-regulate HLA molecules on the infected cell surface, thereby allowing HIV-1 to evade recognition by antiviral CD8+ T lymphocytes....
Topics
- CD8-Positive T-Lymphocytes
- Down-Regulation
- Genetic Variation
- HIV-1
- Histocompatibility Antigens Class I
- Humans
- Immune Evasion
- Virulence Factors
- nef Gene Products, Human Immunodeficiency Virus