Article
CTL-mediated selective pressure influences dynamic evolution and pathogenic functions of HIV-1 Nef.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 2008
Ueno Takamasa, Motozono Chihiro, Dohki Sachi, Mwimanzi Philip, Rauch Susanne, Fackler Oliver T, Oka Shinichi, Takiguchi Masafumi
Abstract excerpt
HIV-1 Nef plays multiple roles in modulating immune responses, even though it is a dominant CTL target itself. How Nef accomplishes the balance between such conflicting selective pressures remains elusive. By genetic and functional studies, we found that Arg75Thr and Tyr85Phe mutations, located in a well-conserved proline-rich region in Nef, were differently associated with escape from CTL responses specific for...
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