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Nef interference with HIV-1–specific CTL antiviral activity is epitope specific

2 Aug 2006

Abstract excerpt

HIV-1 Nef and HIV-1-specific cytotoxic T lymphocytes (CTLs) have important and opposing roles in the immunopathogenesis of HIV-1 infection. Nef-mediated down-modulation of HLA class I on infected cells can confer resistance to CTL clearance, but the factors determining the efficiency of this process are unknown. This study examines the impact of Nef on the antiviral activity of several CTL clones recognizing...

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PMID: 16882705
DOI: 10.1182/blood-2006-06-030668

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