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Article

HIV-1 Vpu Mediates HLA-C Downregulation.

Cell host & microbe - 11 May 2016

Apps Richard, Del Prete Gregory Q, Chatterjee Pramita, Lara Abigail, Brumme Zabrina L, Brockman Mark A, Neil Stuart, Pickering Suzanne, Schneider Douglas K, Piechocka-Trocha Alicja, Walker Bruce D, Thomas Rasmi, Shaw George M, Hahn Beatrice H, Keele Brandon F, Lifson Jeffrey D, Carrington Mary

Abstract excerpt

Many pathogens evade cytotoxic T lymphocytes (CTLs) by downregulating HLA molecules on infected cells, but the loss of HLA can trigger NK cell-mediated lysis. HIV-1 is thought to subvert CTLs while preserving NK cell inhibition by Nef-mediated downregulation of HLA-A and -B but not HLA-C molecules. We find that HLA-C is downregulated by most primary HIV-1 clones, including transmitted founder viruses, in contrast...

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Share to CD4-Positive T-Lymphocytes
Share to Cytotoxicity, Immunologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HLA-C Antigens

Share to Human Immunodeficiency Virus Proteins

Share to Immune Evasion

Share to Killer Cells, Natural

Share to T-Lymphocytes, Cytotoxic

Share to Viral Regulatory and Accessory Proteins

Source

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Identifiers

PMID: 27173934
DOI: 10.1016/j.chom.2016.04.005
PMCID: PMC4904791

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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HIV-1 Vpu Mediates HLA-C Downregulation.PMID 27173934Read ↗

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HLA-B may be more protective against HIV-1 than HLA-A because it resists negative regulatory factor (Nef) mediated down-regulation.Semantic proximity Read ↗

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