Article
Identification of four novel associations for B-cell acute lymphoblastic leukaemia risk.
Nature communications - 25 Nov 2019
Vijayakrishnan Jayaram, Qian Maoxiang, Studd James B, Yang Wenjian, Kinnersley Ben, Law Philip J, Broderick Peter, Raetz Elizabeth A, Allan James, Pui Ching-Hon, Vora Ajay, Evans William E, Moorman Anthony, Yeoh Allen, Yang Wentao, Li Chunliang, Bartram Claus R, Mullighan Charles G, Zimmerman Martin, Hunger Stephen P, Schrappe Martin, Relling Mary V, Stanulla Martin, Loh Mignon L, Houlston Richard S, Yang Jun J
Abstract excerpt
There is increasing evidence for a strong inherited genetic basis of susceptibility to acute lymphoblastic leukaemia (ALL) in children. To identify new risk variants for B-cell ALL (B-ALL) we conducted a meta-analysis with four GWAS (genome-wide association studies), totalling 5321 cases and 16,666 controls of European descent. We herein describe novel risk loci for B-ALL at 9q21.31 (rs76925697, P = 2.11 × 10-8),...
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