Article
A genome-wide association study identifies risk loci for childhood acute lymphoblastic leukemia at 10q26.13 and 12q23.1.
Leukemia - 1 Mar 2017
Vijayakrishnan J, Kumar R, Henrion M Y R, Moorman A V, Rachakonda P S, Hosen I, da Silva Filho M I, Holroyd A, Dobbins S E, Koehler R, Thomsen H, Irving J A, Allan J M, Lightfoot T, Roman E, Kinsey S E, Sheridan E, Thompson P D, Hoffmann P, Nöthen M M, Heilmann-Heimbach S, Jöckel K H, Greaves M, Harrison C J, Bartram C R, Schrappe M, Stanulla M, Hemminki K, Houlston R S
Abstract excerpt
Genome-wide association studies (GWASs) have shown that common genetic variation contributes to the heritable risk of childhood acute lymphoblastic leukemia (ALL). To identify new susceptibility loci for the largest subtype of ALL, B-cell precursor ALL (BCP-ALL), we conducted a meta-analysis of two GWASs with imputation using 1000 Genomes and UK10K Project data as reference (totaling 1658 cases and 7224...
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