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Article

Functional damaging germline variants in ETV6, IKZF1, PAX5 and RUNX1 predisposing to B-cell precursor acute lymphoblastic leukemia.

European journal of medical genetics - 1 Apr 2023

Wagener Rabea, Elitzur Sarah, Brozou Triantafyllia, Borkhardt Arndt

Abstract excerpt

Recent genome-wide studies have demonstrated that a significant proportion of children with cancer carry predisposing germline variants, with varying incidence according to cancer type. In general, there is a lower incidence of underlying germline predisposing variants among patients with B-cell acute lymphoblastic leukemia (B-ALL) compared to other types of cancer, but higher rates may be found in patients with...

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Share to Core Binding Factor Alpha 2 Subunit
Share to ETS Translocation Variant 6 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Germ-Line Mutation

Share to Ikaros Transcription Factor

Share to PAX5 Transcription Factor

Share to Polymorphism, Genetic

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Share to Proto-Oncogene Proteins c-ets

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Identifiers

PMID: 36764385
DOI: 10.1016/j.ejmg.2023.104725

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