Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia.

doi:10.1038/ng.430

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Article

Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia.

Nature genetics - 1 Sept 2009

Papaemmanuil Elli, Hosking Fay J, Vijayakrishnan Jayaram, Price Amy, Olver Bianca, Sheridan Eammon, Kinsey Sally E, Lightfoot Tracy, Roman Eve, Irving Julie A E, Allan James M, Tomlinson Ian P, Taylor Malcolm, Greaves Mel, Houlston Richard S

Abstract excerpt

To identify risk variants for childhood acute lymphoblastic leukemia (ALL), we conducted a genome-wide association study of two case-control series, analyzing the genotypes with respect to 291,423 tagging SNPs in a total of 907 ALL cases and 2,398 controls. We identified risk loci for ALL at 7p12.2 (IKZF1, rs4132601, odds ratio (OR) = 1.69, P = 1.20 x 10(-19)), 10q21.2 (ARID5B, rs7089424, OR = 1.65, P = 6.69 x...

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CCAAT-Enhancer-Binding Proteins

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Chromosomes, Human, Pair 14

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PMID: 19684604
DOI: 10.1038/ng.430
PMCID: PMC4915548

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IKZF1

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