Article
Germline genomic variants associated with childhood acute lymphoblastic leukemia.
Nature genetics - 1 Sept 2009
Treviño Lisa R, Yang Wenjian, French Deborah, Hunger Stephen P, Carroll William L, Devidas Meenakshi, Willman Cheryl, Neale Geoffrey, Downing James, Raimondi Susana C, Pui Ching-Hon, Evans William E, Relling Mary V
Abstract excerpt
Using the Affymetrix 500K Mapping array and publicly available genotypes, we identified 18 SNPs whose allele frequency differed significantly(P < 1 x 10(-5)) between pediatric acute lymphoblastic leukemia (ALL) cases (n = 317) and non-ALL controls (n = 17,958). Two SNPs in ARID5B not only differed between ALL and non-ALL groups (rs10821936, P = 1.4 x 10(-15), odds ratio (OR) = 1.91; rs10994982, P = 5.7 x 10(-9),...
Topics
Join the communities discussing this publication.